Disclaimer

Key Limitations

1. Polygenic risk scores are statistical estimates, not certainties. A higher-than-average score means published research associates your combination of genetic variants with a statistically elevated likelihood compared to the general study population. It does not mean you will develop any condition.
2. GWAS studies have population representation gaps. The majority of genome-wide association studies have been conducted on populations of European descent. If your ancestry differs, the statistical associations may be less applicable. ExomeDNA displays a confidence rating for each trait that reflects study population diversity among other factors.
3. Genetics is one factor among many. Research suggests that most complex traits are influenced by a combination of genetic variants, environmental factors, lifestyle choices, and random biological variation.
4. Scientific understanding evolves. GWAS findings are based on the current state of published research. As new studies are published, risk estimates may change.
5. Genotyping chip coverage varies. Consumer DNA services test a subset of your genome. The number of variants relevant to each trait captured by your chip varies. ExomeDNA reports matched variants and total known variants for each trait.
6. Monogenic traits have different implications. Some results reflect well-characterized single-gene variants. These are labeled distinctly from polygenic risk scores. Even well-studied single-gene variants do not guarantee a particular outcome — many people with such variants never develop the associated condition.
7. This analysis does not detect all genetic variants. Consumer chips do not capture structural variants, copy number variants, epigenetic modifications, or many rare variants. A typical result does not rule out risk factors not tested.
8. AI-generated explanations are educational, not clinical. The AI Health Coach is an artificial intelligence model, not a licensed healthcare professional, and cannot account for your complete medical history or clinical context.

What You Should Do

• Douse results as a starting point for conversations with your healthcare provider
• Doconsider consulting a certified genetic counselor (findageneticcounselor.com)
• Doreview cited research studies linked on each trait card
• Do notmake medication, treatment, or dietary changes based solely on these results
• Do notuse results to self-diagnose any medical condition
• Do notproactively disclose these results to insurers for life, disability, or long-term care coverage without consulting a genetic counselor about your rights — GINA protections do not extend to these insurance types